VirtualBox will not start and present a Critical Error dialog box which reads “Failed to create the VirtualBox COM object. The application will now terminate.” If you select Details for additional information, it may offer something similar to this error, if not the same, Callee RC: CO_E_SERVER_EXEC_FAILURE (0x80080005). Here is a solution that worked in this case and will get VirtualBox back up and running without losing any configuration changes.

I recognize this error will likely occur on multiple versions of this application, however, for the sake of disclosure, the error occured using Oracle VirtualBox 4.3.6 on a Microsoft Windows 7 Professional (64-bit). During the re-install, I elected to upgrade to the latest, at the time of this writing, Oracle VirtualBox 4.3.8.
The Process
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- Navigate to your profile and look for the .VirtualBox folder. For example, C:Usersyour.name.VirtualBox
- Copy the VirtualBox.xml to somewhere safe, like your desktop
- Uninstall VirtualBox
- Delete the .VirtualBox folder
- Re-install VirtualBox and the option package.
- Start VirtualBox
- Close VirtualBox
- Navigate to your profile and look for the .VirtualBox folder. For example, C:Usersyour.name.VirtualBox
- Rename the VirtualBox.xml to VirtualBox.xml.old
- Copy your original VirtualBox.xml to the .VirtualBox folder
- Start VirtualBox
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Note: If you are presented with a hardware error message of some sort, here the corrections may be made. In my case, there was a referenced hard disk that was unavailable. So I deleted it using the configuration window that was presented.
Hackboot 1 / Hackboot 2: Even though it’s called a “bootable DVD”, the Olarila version of OS X Mountain Lion still can’t boot in Virtualbox by itself. To help Mountain Lion start, you’ll need to use Olarila’s Hackboot CD. There are three different versions of Hackboot; we’ll need to use two of them in this guide.
Everything should be working as expected.